An account of the experiment of transfusion, practiced upon a man in London. 1667.

lThis waspetforn 'd, Novemb. 23, 1667, upon on Mr Arthur Coga, at Arundelhouse, in the presence of many considerable and intelligent persons by the management of those two Learned Physicians and dextrouis Anatomists, Dr Richard Lower, andDr Edmund King, the latter of whom communicated the Relation of it, as followeth. The Experiment of Transfusion of Blood into an human Vein was made by Us in this manner. Having prepared the CarotidArtery in a young Sheep, we inserted a Silver-Pipe into the Quills to let the Blood run through it into a Porringer, and in the space of almost a minute, about 12 ounces of the sheeps blood ran through the Pipe into the Porringer; which was somewhat to direct us in the quantity of Blood now to be transfus'd into the Man. Which done, when we came to prepare the Vein in the Man's Arm, the Vein seem'd too small for that Pipe, which we intended to insert into it; so that we employed another, about one third part less, at the little end. Then we made an incision in the Vein, after the method formerly publisht, Numb. 28; which method we observ'd without any other alteration, but in the shape of one or our Pipes; which we found more convenient for our purpose. And, having open'd the Vein in the Man's Arm, with as much ease as in the common way of Venae-section, we let thence run out 6 or 7 Ounces of Blood. Then we planted our silver Pipe into the said Incision, and inserted Quills between the two Pipes already advanced in the two subjects, to convey the Arterial blood from the Sheep into the Vein of the Man. But this Blood was near a minute, before it had passed through the Pipes and Quills into the Arm; and then it ran freely into the Man's Vein for the space of 2 minutes at least; so that we could feel a pulse in the said Vein just beyond the end of the silver Pipe; though the Patient said, he did not feel the Blood hot (as we reported of the subject in the French Experiment) which may very well be imputed to the length of the Pipes, through which the blood passed, losing thereby so much of its heat, as to come in a temper very agreeable to Venal Blood. And as to the quantity of Blood receiv'd into the Man's Vein, we judge, there was about 9 or 10 ounces: For, allowing this Pipe was less than that, through which 12 ounces pass'd in one minute before, we may very well suppose, it might in 2 minutes convey as much blood into the Vein, as the other did in the Porringer in one minute; granting withall, that the Blood did not run so vigorously the second minute, as it did the first, nor the third, as the second, &c. But that the Blood did run